Bioactive Small Molecules
Cayman Chemical nlumbo nucIfera LotusIn 5mg
An alkaloid with diverse biological activities; increases cAMP levels in rat myocardium at 0.1-3 µM and cGMP levels in rabbit corpus cavernosum in a concentration-dependent manner; prevents doxorubicin-induced lipid peroxidation in H9c2 embryonic rat cardiomyocytes; increases LVP, LVEDP, and SAP in anesthetized rats at 5 mg/kg
Cayman Chemical ANTIBODY LXS-196 5mg
A PKC inhibitor (IC50s = 1.9 and 0.4 nM for PKCα and PKCθ, respectively); selective for PKCα and PKCθ over GSK3β (IC50 = 3,100 nM); inhibits proliferation of TMD8 B cell lymphoma and 92.1 uveal melanoma cells (IC50s = 900 and 184 nM, respectively) but not SK-MEL-28 skin melanoma cells (IC50 = >10,000 nM)
Apexbio Technology LLC Apigenin, 10mM (in 1mL DMSO) CAS# 520-36-5
Apigenin is an antioxidant plant flavanoid which contains anti-inflammatory and anticancer properties. It may induce apoptosis and may inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Is also known to be a MAP kinase inh Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC GNE-049 | 1936421-41-8 | 99.7% | 510.58 | 100 MG
GNE-049 is a highly potent and selective CBP inhibitor. It demonstrates excellent potency in BRET cellular assays and inhibits MYC expression in MV4-11 cell lines. The compound exhibits acceptable pharmacokinetic properties and selectively targets CBP/P300 with high selectivity over BRD4(1), and can penetrate the central nervous system (CNS).
- Highly potent and selective CBP inhibitor (IC50 of 1.1 nM in TR-FRET assay).
- Inhibits BRET (IC50 12 nM) and BRD4(1) (IC50 4200 nM).
- Acceptable pharmacokinetic properties in mouse, rat, dog, and monkey.
- High selectivity for CBP/P300 (3820-fold over BRD4(1)).
- Penetrates the central nervous system.
- Inhibits MYC expression (EC50 of 14 nM in MV4-11 cell line).
- Selected for balance of liver microsome stability, selectivity, and cellular potency.
Cayman Chemical S-4-nItro-BlebbIstatIn 5mg
A more stable and less phototoxic form of (–)-blebbistatin; less inherent fluorescence, more photostable, and less phototoxic than (–)-blebbistatin while retaining the in vitro and in vivo activity; has the same stereochemistry as (–)-blebbistatin
Cayman Chemical ANTIBODY MK-1775 5mg
An inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM) that prevents phosphorylation of Cdc2 at tryosine15, which abrogates the G2 DNA damage checkpoint; induces apoptosis in combination with several DNA damaging agents selectively in p53-deficient tumor cell lines
Cayman Chemical ANTIBODY CU-32 5mg
A cGAS inhibitor (IC50 = 0.45 µM); reduces DNA-, but not Sendai virus-, induced IRF3 dimerization in THP-1 cells, indicating cGAS pathway selectivity; selective for cGAS over TLRs at 50 µM; decreases IFN-stimulatory DNA-induced IFN-β production in THP-1 cells at 10, 30, and 100 µM
Medchemexpress LLC HY-B0873 500mg Medchemexpress, Uniconazole CAS:83657-22-1 Purity:>98%
Medchemexpress, HY-B0873 500mg Uniconazole CAS:83657-22-1 Uniconazole is a plant growth regulator that functions by inhibiting cytochrome P450 707As (Ki=68 nM), a family of enzymes that catabolize Abscisic acid, and thus, suppress gibberellin and sterol biosynthesis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-Y0123 500mg Medchemexpress, DL-Tyrosine CAS:556-03-6 Purity:>98%
Medchemexpress, HY-Y0123 500mg DL-Tyrosine CAS:556-03-6 DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
AdipoGen Dasatinib
Chemical. CAS 302962-49-8. Formula C22H26ClN7O2S. MW 488. Dasatinib is a potent multi-kinase inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family. Dasatinib is a highly potent pan-Src/Bcr-Abl inhibitor Ki values are 16 and 30 pM, respectively. It is also effective at sub-nanomolar concentrations, inhibiting Lyn, Fyn, EPHA2, PDGFR, c-Kit, Lck and Yes. At nanomolar concentrations, Dasatinib also blocks the activity of several other receptor and non-receptor tyrosine kinases, plus drug resistant mutants. Dasatinib has potential therapeutic value in diseases that are characterized by elevated levels of these kinases, including some forms of cancer and fibrotic disease. It suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells.
Cayman Chemical ANTIBODY L202 10mg
An ionizable cationic lipid (pKa = 6.04); intramuscular administration of LNPs containing L202 and encapsulating nucleoside-modified mRNA encoding pre-fusion stabilized SARS-CoV-2 spike glycoprotein increase plasma levels of IgG antibodies targeting SARS-CoV-2 spike glycoprotein in mice and cynomolgus monkeys
Medchemexpress LLC Bempedoic acid-d4 | 2408131-70-2 | 98.0% | 348.51 g/mol | C19H32D4O5 | 1MG
Bempedoic acid-d4 is the deuterium-labeled analog of bempedoic acid provided for research use as an analytical tracer and internal standard. It is intended for use in mass spectrometry quantitation and pharmacokinetic studies and corresponds to the biological target profile of bempedoic acid as an ATP-citrate lyase inhibitor with reported AMPK activity. Store and handle following the supplier datasheet recommendations.
- Deuterium-labeled internal standard for mass spectrometry.
- Suitable for pharmacokinetic and tracer studies.
- Retains ATP-citrate lyase inhibitory activity for biological reference.
- High purity suitable for analytical applications.
- Stable when stored under recommended conditions.
Medchemexpress LLC Lodenafil (hydroxyhomosildenafil) | 139755-85-4 | MFCD00908400 | 99.9% | 504.60 g·mol-1 | C23H32N6O5S | 10MG
Lodenafil (hydroxyhomosildenafil) is a research-grade phosphodiesterase type 5 (PDE5) inhibitor used in studies of erectile dysfunction and related pharmacology. It is supplied as a high-purity small molecule with available solid and solution forms, and is accompanied by analytical and safety documentation to support laboratory use.
- High purity suitable for research applications.
- Available in multiple solid sizes and as a 10 mM solution in DMSO.
- Provided with analytical data, including HNMR and LCMS.
- Includes certificate of analysis and safety data sheet for handling and compliance.
- Molecular formula C23H32N6O5S and molecular weight 504.60 g·mol-1.
Medchemexpress LLC Anthraquinone-2-carboxylic acid | 117-78-2 | MFCD00001231 | 98.0% | 252.22 g/mol | C15H8O4 | 1 ML
Anthraquinone-2-carboxylic acid is an anthraquinone derivative isolated from Brazilian taheebo with reported anti-inflammatory and antinociceptive activity. It is supplied for research use in powder form or as a 10 mM solution in DMSO, and is intended for in vitro applications when handled and stored per recommended conditions.
- CAS number 117-78-2.
- Purity 98.0%.
- Molecular formula C15H8O4; molecular weight 252.22 g/mol.
- Available as powder and as a 10 mM solution in DMSO (1 mL).
- Soluble in DMSO at 25 mg/mL (≈99.12 mM); ultrasonic assistance recommended.
- Powder storage: -20°C (3 years) or 4°C (2 years).
- In-solvent storage: -80°C (6 months) or -20°C (1 month).
- For research use only.
Cayman Chemical ANTIBODY MBQ-167 10mg
A dual inhibitor of Rac and Cdc42 (IC50s = 103 and 78 nM, respectively); reduces Rac and Cdc42 GTP-binding and GTPase activity and limits migration and mammosphere formation in MDA-MB-231 cells at 250 nM; reduces cell viability and induces apoptosis at 250 nM in lapatinib-resistant SK-BR-3 and MDA-MB-435 cells alone or with lapatinib; reduces growth rates, axial budding, and Cdc42 activity in S. cerevisiae at 200 µM; reduces tumor growth in an MDA-MB-435 mouse xenograft model at 1 or 10 mg/kg three times per week, i.p.